FKBP4

Across TCGA pan-cancer cohorts, FKBP4 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of FKBP4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where FKBP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FKBP4 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

BLCA, THCA, and COAD are the cancer types where FKBP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FKBP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+1.448	<.001	11	view →
THCA	All	IV	−1.152	<.001	11	view →
COAD	Male	IV	+1.022	<.001	11	view →
KIRC	Male	II,III,IV	−0.747	<.001	11	view →
LUAD	Male	II,III,IV	+1.235	<.001	9	view →
LIHC	Male	All	+0.860	<.001	9	view →
LUSC	Female	All	+2.237	<.001	8	view →
STAD	Male	II,III,IV	+0.969	<.001	8	view →
HNSC	Male	All	+0.865	<.001	8	view →
BRCA	All	III,IV	+1.694	<.001	6	view →
UCEC	All	All	+0.722	.001	6	view →
READ	All	All	+0.962	.002	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

FKBP4–BLCA

Open the BLCA breakdown →