FKBP1B

Across TCGA pan-cancer cohorts, FKBP1B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FKBP1B data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FKBP1B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FKBP1B expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRP show a favorable association.

ACC, SCLC, and LGG are the cancer types where FKBP1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.225	0.695	<.001	93	view →
SCLC	OS	Median	All	0.842	0.562	<.001	70	view →
LGG	DFS	Median	All	0.668	0.803	<.001	53	view →
SKCM	DFS	Median	All	0.650	0.856	<.001	44	view →
KIRP	DFS	Quartile	All	0.962	0.795	.002	24	view →
LAML	DFS	Quartile	All	0.543	0.231	.005	24	view →
MESO	OS	Median	III,IV	0.317	0.519	.009	21	view →
LUAD	DFS	Tertile	IV	0.728	0.360	.012	16	view →
GBM	OS	Median	All	0.218	0.314	.019	12	view →
STAD	OS	Median	II,III,IV	0.305	0.510	.033	12	view →
LIHC	OS	Median	II,III,IV	0.247	0.578	.013	11	view →
CHOL	DFS	Median	IV	0.858	0.339	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FKBP1B–ACC (DFS)

Open the ACC breakdown →