FKBP1B

Across TCGA pan-cancer cohorts, FKBP1B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FKBP1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FKBP1B RNA is repressed in tumor relative to normal tissue. In most cancer types FKBP1B is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where FKBP1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FKBP1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.106	<.001	12	view →
COAD	Female	II,III,IV	−1.384	<.001	11	view →
KIRP	All	II,III,IV	−1.476	<.001	10	view →
KICH	Female	II,III,IV	−2.692	<.001	9	view →
LUAD	Female	III,IV	−1.654	<.001	9	view →
LUSC	Female	II,III,IV	−1.380	<.001	7	view →
BRCA	Female	All	−0.486	<.001	6	view →
HNSC	Male	III,IV	+0.781	.021	2	view →
STAD	All	II,III,IV	+0.656	.007	2	view →
READ	All	All	−0.970	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FKBP1B–KIRC

Open the KIRC breakdown →