FKBP1B

Across TCGA pan-cancer cohorts, FKBP1B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FKBP1B’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where FKBP1B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FKBP1B is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

CCRCC, PDAC, and HNSC are the cancer types where FKBP1B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FKBP1B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	+0.476	<.001	11	view →
PDAC	All	III,IV	−0.698	<.001	9	view →
HNSC	All	III,IV	−2.620	<.001	8	view →
LSCC	All	II,III,IV	−0.688	<.001	8	view →
LUAD	Female	II,III,IV	−0.396	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FKBP1B–CCRCC

Open the CCRCC breakdown →