FKBP1A

Across TCGA patient cohorts, FKBP1A mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP1A-associated genes across cancer lineages are 14-3-3_beta, FOXO3a_pS318_S321, and ACC1. Each is linked with FKBP1A in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP1A-to-partner and partner-to-FKBP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FKBP1A-low versus FKBP1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP1A→partner) and Y-score (partner→FKBP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.105	-2.973	.030	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.163	-2.449	.006	.019	3	1
UCEC	ACC1 →	+0.459	+2.820	.008	.035	3	1
UCEC	Ku80 →	+0.377	+2.183	<.001	.033	3	1
UCEC	mTOR_pS2448 →	-0.185	-2.302	.010	.034	3	1
UCEC	p27_pT198 →	+0.112	+3.169	.031	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

14-3-3_beta by FKBP1A expression — UCEC

Explore this box plot interactively →