FKBP1A

Across TCGA pan-cancer cohorts, FKBP1A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FKBP1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FKBP1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FKBP1A is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where FKBP1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FKBP1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.349	<.001	12	view →
KIRC	Female	All	+1.000	<.001	12	view →
STAD	Female	All	+1.110	<.001	10	view →
LIHC	Female	II,III,IV	+1.401	<.001	9	view →
THCA	Male	III,IV	−0.927	<.001	9	view →
BLCA	Female	III,IV	+0.588	<.001	9	view →
LUAD	All	II,III,IV	−0.339	<.001	7	view →
BRCA	Female	All	+0.153	.007	6	view →
CHOL	Male	All	+2.603	<.001	5	view →
ESCA	All	All	+1.269	<.001	5	view →
KICH	Female	All	−1.014	<.001	4	view →
COAD	All	All	−0.312	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FKBP1A–HNSC

Open the HNSC breakdown →