FKBP14

Across TCGA patient cohorts, FKBP14 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP14-associated genes across cancer lineages are EGFR, A-Raf_pS299, and Ku80. Each is linked with FKBP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP14-to-partner and partner-to-FKBP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by FKBP14-low versus FKBP14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP14→partner) and Y-score (partner→FKBP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.213	-2.321	.008	.035	3	1
UCEC	A-Raf_pS299 →	-0.132	-3.169	.027	.019	3	1
UCEC	Ku80 →	+0.265	+2.335	.025	.020	3	1
UCEC	Rab25 →	-0.353	-2.321	.034	.035	3	1
UCEC	Src_pY416 →	-0.251	-2.308	.038	.036	3	1
UCEC	TFRC →	+0.710	+2.321	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR by FKBP14 expression — UCEC

Explore this box plot interactively →