FKBP14

Across TCGA pan-cancer cohorts, FKBP14 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FKBP14’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FKBP14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FKBP14 is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where FKBP14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FKBP14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.941	<.001	12	view →
COAD	Male	II,III,IV	+0.827	<.001	10	view →
KIRP	All	III,IV	+1.142	<.001	9	view →
LUAD	All	III,IV	+0.939	<.001	9	view →
LIHC	Female	II,III,IV	+0.935	<.001	8	view →
LUSC	Male	All	+0.920	<.001	7	view →
KIRC	Male	All	+0.443	<.001	7	view →
CHOL	Male	All	+1.760	<.001	5	view →
READ	Male	All	+1.163	.024	4	view →
BLCA	Female	All	+0.501	.023	4	view →
THCA	All	All	−0.281	.001	4	view →
STAD	All	II,III,IV	+0.536	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FKBP14–HNSC

Open the HNSC breakdown →