FKBP11

Across TCGA patient cohorts, FKBP11 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP11-associated genes across cancer lineages are SNX18P23, RNY4P29, and RN7SKP43. Each is linked with FKBP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP11-to-partner and partner-to-FKBP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX18P23 grouped by FKBP11-low versus FKBP11-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP11→partner) and Y-score (partner→FKBP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SNX18P23 →	+0.057	+4.653	<.001	.007	3	2
SKCM	RNY4P29 →	+0.993	+7.816	<.001	.008	3	2
UCEC	RN7SKP43 →	+0.109	+4.137	.004	.008	3	2
UCEC	MIR2115 →	+0.433	+3.344	<.001	.007	3	2
UCEC	RNU6-218P →	+0.730	+3.126	<.001	.004	3	2
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

SNX18P23 by FKBP11 expression — READ

Explore this box plot interactively →