FKBP10

Across TCGA patient cohorts, FKBP10 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP10-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and eIF4G. Each is linked with FKBP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP10-to-partner and partner-to-FKBP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FKBP10-low versus FKBP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP10→partner) and Y-score (partner→FKBP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.136	+2.584	.015	.010	3	2
UCEC	EGFR_pY1068 →	-0.235	-2.700	.017	.006	3	1
UCEC	eIF4G →	+0.248	+2.000	.042	.030	3	1
UCEC	ERK2 →	+0.156	+1.584	.039	.036	3	1
UCEC	FoxM1 →	+0.206	+2.000	.043	.010	3	1
UCEC	INPP4B →	-0.308	-3.321	.015	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

C-Raf by FKBP10 expression — UCEC

Explore this box plot interactively →