FKBP10

Across TCGA pan-cancer cohorts, FKBP10 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FKBP10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FKBP10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FKBP10 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where FKBP10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FKBP10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.423	<.001	12	view →
KIRC	Female	IV	+3.138	<.001	12	view →
COAD	Male	III,IV	+2.418	<.001	11	view →
LUAD	All	III,IV	+1.613	<.001	9	view →
STAD	Male	II,III,IV	+2.258	<.001	8	view →
BRCA	All	III,IV	+1.098	<.001	8	view →
LUSC	Male	II,III,IV	+1.654	<.001	6	view →
CHOL	Female	All	+4.273	<.001	5	view →
LIHC	Female	All	+1.219	.001	4	view →
KICH	Female	II,III,IV	−1.491	.005	3	view →
ESCA	Female	All	+2.976	.030	2	view →
READ	All	All	+1.730	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FKBP10–HNSC

Open the HNSC breakdown →