FIZ1

Across TCGA patient cohorts, FIZ1 mutation is significantly associated with the RNA expression of many other genes, with 154 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIZ1-associated genes across cancer lineages are RNA5SP432, RNU6-1292P, and KRTCAP2. Each is linked with FIZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIZ1-to-partner and partner-to-FIZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP432 grouped by FIZ1-low versus FIZ1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIZ1→partner) and Y-score (partner→FIZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP432 →	+0.255	+4.539	.001	.008	3	2
UCEC	RNU6-1292P →	+0.262	+3.231	<.001	.004	3	2
UCEC	KRTCAP2 →	-0.593	-3.767	<.001	<.001	3	1
UCEC	ABLIM2 →	-0.534	-2.906	.007	.002	3	1
UCEC	FOXQ1 →	-1.381	-2.906	.001	.002	3	1
UCEC	AHSP →	+0.208	+2.619	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 154 associations by consensus.

RNA5SP432 by FIZ1 expression — CESC

Explore this box plot interactively →