FIZ1

Across TCGA pan-cancer cohorts, FIZ1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated FIZ1 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher FIZ1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FIZ1 expression acts as an unfavorable survival marker, although some lineages such as UVM and SCLC show a favorable association.

MESO, UVM, and SCLC are the cancer types where FIZ1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.289	0.757	.001	94	view →
UVM	DFS	Quartile	All	0.828	0.386	<.001	71	view →
SCLC	DFS	Quartile	II,III,IV	0.791	0.285	.003	68	view →
ACC	OS	Median	All	0.443	0.776	<.001	66	view →
LIHC	OS	Tertile	II,III,IV	0.348	0.706	<.001	60	view →
SKCM	OS	Tertile	All	0.715	0.838	<.001	50	view →
BLCA	OS	Quartile	All	0.792	0.580	<.001	44	view →
LGG	DFS	Median	All	0.316	0.472	<.001	36	view →
THYM	DFS	Median	All	0.882	0.615	.001	28	view →
HNSC	DFS	Quartile	All	0.773	0.633	.004	26	view →
GBM	DFS	Median	All	0.386	0.180	.001	23	view →
BRCA	OS	Median	All	0.946	0.902	.005	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

FIZ1–MESO (OS)

Open the MESO breakdown →