FIZ1

Across TCGA patient cohorts, FIZ1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIZ1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, MSH2, and mTOR_pS2448. Each is linked with FIZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIZ1-to-partner and partner-to-FIZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by FIZ1-low versus FIZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIZ1→partner) and Y-score (partner→FIZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.530	+3.179	.031	.010	3	1
UCEC	MSH2 →	-0.382	-2.973	<.001	.035	3	1
UCEC	mTOR_pS2448 →	-0.173	-2.459	.016	.020	3	1
UCEC	p62 Lck ligand →	+0.396	+3.179	.011	.010	3	1
UCEC	beta-Catenin →	+0.518	+2.999	.034	.035	3	1
UCEC	c-Kit →	-0.259	-2.459	.021	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Acetyl-a-Tubulin-Lys40 by FIZ1 expression — UCEC

Explore this box plot interactively →