FIZ1

Across TCGA cell cohorts, FIZ1 mutation is significantly associated with the RNA expression of many other genes, with 213 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FIZ1-associated genes across cancer lineages are SPINK8, OR52B2, and NKX2-6. Each is linked with FIZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIZ1-to-partner and partner-to-FIZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK8 grouped by FIZ1-low versus FIZ1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIZ1→partner) and Y-score (partner→FIZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SPINK8 →	+0.137	+4.736	<.001	.009	3	2
BLOOD_Lymphoma	OR52B2 →	+0.022	+3.714	.001	.006	3	2
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LUNG_SCLC	REG3G →	+0.098	+3.938	<.001	<.001	3	1
LUNG_SCLC	TCP10L2 →	+0.756	+3.750	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 213 associations by consensus.

SPINK8 by FIZ1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →