Across TCGA patient cohorts, FIS1 mutation is significantly associated with the RNA expression of many other genes, with 161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIS1-associated genes across cancer lineages are RNA5SP414, MIR8071-2, and RNU6-819P. Each is linked with FIS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIS1-to-partner and partner-to-FIS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIS1→partner) and Y-score (partner→FIS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.548	+2.380	<.001	.002	3	1
UCEC	MIR8071-2 →	+1.065	+2.959	.001	<.001	3	1
COAD	RNU6-819P →	+0.427	+7.741	<.001	.009	3	1
UCEC	MYO19 →	+0.562	+2.650	.001	.005	3	1
UCEC	MIR6803 →	+0.161	+4.571	<.001	.002	3	1
UCEC	FAM27B →	+0.069	+3.231	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 161 associations by consensus.

Exploration

FIS1 survival (RNA) · tumor vs normal (RNA) · all FIS1 data types