FIGNL2

Across TCGA pan-cancer cohorts, FIGNL2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FIGNL2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FIGNL2 RNA is repressed in tumor relative to normal tissue. In most cancer types FIGNL2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where FIGNL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FIGNL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.400	<.001	11	view →
HNSC	All	All	+0.144	<.001	10	view →
LIHC	Male	All	+0.645	<.001	8	view →
BRCA	All	All	−0.317	<.001	6	view →
KIRC	Male	All	−0.307	.010	4	view →
STAD	All	All	+0.301	.018	4	view →
THCA	All	All	+0.220	.015	2	view →
CHOL	Male	All	+0.803	.047	1	view →
LUAD	Male	III,IV	+0.528	.033	1	view →
ESCA	Male	All	+0.460	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FIGNL2–KICH

Open the KICH breakdown →