FIGNL2-DT

Across TCGA pan-cancer cohorts, FIGNL2-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FIGNL2-DT data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FIGNL2-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FIGNL2-DT expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCS show a favorable association.

UCEC, MESO, and UVM are the cancer types where FIGNL2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.489	0.658	<.001	68	view →
MESO	OS	Tertile	II,III,IV	0.278	0.539	<.001	66	view →
UVM	DFS	Quartile	III,IV	0.330	0.640	.016	46	view →
STAD	OS	Median	II,III,IV	0.480	0.649	.005	31	view →
KIRC	DFS	Tertile	II,III,IV	0.407	0.596	.009	29	view →
KIRP	DFS	Tertile	All	0.897	0.577	.010	28	view →
UCS	OS	Quartile	II,III,IV	0.662	0.258	.024	26	view →
ESCA	OS	Median	IV	0.698	0.222	.006	18	view →
READ	OS	Median	II,III,IV	0.984	0.870	.012	17	view →
LUAD	OS	Tertile	II,III,IV	0.652	0.471	.010	13	view →
LIHC	DFS	Quartile	II,III,IV	0.220	0.549	.003	13	view →
BRCA	OS	Quartile	All	0.982	0.956	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FIGNL2-DT–UCEC (DFS)

Open the UCEC breakdown →