FIGNL2-DT

Across TCGA pan-cancer cohorts, FIGNL2-DT RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FIGNL2-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FIGNL2-DT RNA is repressed in tumor relative to normal tissue. In most cancer types FIGNL2-DT is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where FIGNL2-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FIGNL2-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.468	<.001	10	view →
THCA	Male	All	+1.562	<.001	9	view →
LIHC	Female	II,III,IV	+0.824	<.001	8	view →
BRCA	Female	All	−0.718	<.001	6	view →
KIRC	Female	All	+0.509	.002	5	view →
LUSC	Male	All	−0.225	<.001	4	view →
LUAD	All	All	+0.271	.008	2	view →
HNSC	Female	III,IV	+0.104	.030	2	view →
CHOL	All	All	+1.382	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FIGNL2-DT–KICH

Open the KICH breakdown →