FIGNL1

Across TCGA patient cohorts, FIGNL1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,769 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FIGNL1-associated genes across cancer lineages are E2F3, TENT4A, and NCAPH. Each is linked with FIGNL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FIGNL1-to-partner and partner-to-FIGNL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FIGNL1 versus E2F3 in LUAD, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIGNL1→partner) and Y-score (partner→FIGNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	E2F3 →	+0.938	+0.831	<.001	<.001	3	4
LSCC	TENT4A →	+0.468	+0.510	.001	<.001	3	4
LUAD	NCAPH →	+1.097	+0.727	<.001	<.001	3	4
LUAD	CKAP2L →	+1.313	+0.661	<.001	<.001	3	4
LSCC	TYMS →	+0.755	+0.373	<.001	<.001	3	4
LSCC	HMGXB4 →	+0.520	+0.395	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,769 associations by consensus.

FIGNL1 vs E2F3 — LUAD

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