FIGNL1

Across TCGA patient cohorts, FIGNL1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIGNL1-associated genes across cancer lineages are FASN, Heregulin, and JNK_pT183_Y185. Each is linked with FIGNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIGNL1-to-partner and partner-to-FIGNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by FIGNL1-low versus FIGNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIGNL1→partner) and Y-score (partner→FIGNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.300	+2.459	.047	.019	3	2
UCEC	Heregulin →	-0.101	-2.115	.032	.017	3	2
UCEC	JNK_pT183_Y185 →	-0.171	-2.321	.008	.034	3	2
UCEC	Notch1 →	+0.171	+3.710	.001	<.001	3	2
UCEC	TFRC →	+0.409	+2.999	.044	.035	3	2
UCEC	ASNS →	+0.351	+2.584	.011	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FASN by FIGNL1 expression — UCEC

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