Across TCGA patient cohorts, FICD mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FICD-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and FOXO3a_pS318_S321. Each is linked with FICD in more than 1 cancer types. Because this analysis shows association rather than direction, both FICD-to-partner and partner-to-FICD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FICD→partner) and Y-score (partner→FICD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.235	-3.459	.023	.005	3	2
UCEC	mTOR_pS2448 →	-0.164	-3.439	.007	.005	3	2
UCEC	FOXO3a_pS318_S321 →	-0.106	-3.312	.039	.010	3	1
UCEC	GATA6 →	-0.141	-1.693	.031	.044	3	1
UCEC	MSH2 →	-0.265	-3.143	.005	.018	3	1
UCEC	p27_pT198 →	+0.108	+2.459	.014	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

FICD survival (RNA) · tumor vs normal (RNA) · all FICD data types