FIBP

Across TCGA patient cohorts, FIBP mutation is significantly associated with the RNA expression of many other genes, with 1,326 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIBP-associated genes across cancer lineages are TRDD1, TRAJ46, and COX5A. Each is linked with FIBP in more than 1 cancer types. Because this analysis shows association rather than direction, both FIBP-to-partner and partner-to-FIBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDD1 grouped by FIBP-low versus FIBP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIBP→partner) and Y-score (partner→FIBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	2
COAD	TRAJ46 →	+0.852	+4.516	<.001	.009	3	2
UCEC	COX5A →	+0.498	+3.499	.001	.002	3	1
UCEC	TUFM →	+0.454	+3.917	.003	<.001	3	1
UCEC	PLD6 →	+0.772	+2.839	<.001	.001	3	1
UCEC	FCER1A →	-0.823	-3.560	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,326 associations by consensus.

TRDD1 by FIBP expression — BRCA

Explore this box plot interactively →