FHL5

Across TCGA patient cohorts, FHL5 mutation is significantly associated with the RNA expression of many other genes, with 2,753 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FHL5-associated genes across cancer lineages are PHB, TRAIP, and SMIM4. Each is linked with FHL5 in more than 3 cancer types. Because this analysis shows association rather than direction, both FHL5-to-partner and partner-to-FHL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHB grouped by FHL5-low versus FHL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL5→partner) and Y-score (partner→FHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHB →	+0.541	+4.321	.002	<.001	3	3
SKCM	TRAIP →	+0.473	+2.989	.006	<.001	2	4
UCEC	SMIM4 →	+0.631	+3.290	<.001	<.001	3	3
UCEC	FGFR2 →	-1.141	-2.799	<.001	.003	3	3
SKCM	MAOB →	-1.560	-3.296	.003	.009	3	3
SKCM	CELSR3 →	+0.733	+3.331	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,753 associations by consensus.

PHB by FHL5 expression — UCEC

Explore this box plot interactively →