FHL5

Across TCGA cell cohorts, FHL5 RNA expression is significantly associated with the mutation status of many other genes, with 115 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible FHL5-associated genes across cancer lineages are NOTCH4, IQGAP2, and CHD7. Each is linked with FHL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FHL5-to-partner and partner-to-FHL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOTCH4 grouped by FHL5-low versus FHL5-high in URINARY_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL5→partner) and Y-score (partner→FHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NOTCH4 →	+4.087	+0.010	.009	<.001	3	2
LUNG_NSCLC_LUSC	IQGAP2 →	+4.643	+0.023	.008	<.001	3	2
LUNG_NSCLC_LUSC	CHD7 →	+4.643	+0.023	.008	<.001	3	2
LUNG_NSCLC_LUSC	SPAM1 →	+4.643	+0.023	.008	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ITGB1 →	+4.510	+0.041	.003	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	SRRM2 →	+3.510	+0.033	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

NOTCH4 by FHL5 expression — URINARY_TRACT

Explore this box plot interactively →