FHL1

Across TCGA patient cohorts, FHL1 mutation is significantly associated with the RNA expression of many other genes, with 2,750 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FHL1-associated genes across cancer lineages are RN7SL248P, RNA5SP412, and OR6P1. Each is linked with FHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FHL1-to-partner and partner-to-FHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by FHL1-low versus FHL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL1→partner) and Y-score (partner→FHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL248P →	+0.068	+5.263	<.001	.001	3	2
UCEC	RNA5SP412 →	+0.391	+1.568	<.001	.002	3	2
CESC	OR6P1 →	+0.023	+4.247	<.001	.007	3	2
CESC	SNRPGP6 →	+0.089	+4.516	<.001	.004	3	2
BRCA	RNU6-1122P →	+0.183	+4.505	<.001	.006	3	2
SKCM	OR1C1 →	+0.145	+3.875	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,750 associations by consensus.

RN7SL248P by FHL1 expression — CESC

Explore this box plot interactively →