FH

Across TCGA patient cohorts, FH protein abundance is significantly associated with the RNA expression of many other genes, with 17,624 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FH-associated genes across cancer lineages are PMP22, F13A1, and CHN1. Each is linked with FH in more than 5 cancer types. Because this analysis shows association rather than direction, both FH-to-partner and partner-to-FH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FH versus PMP22 in OV, with a Pearson correlation of -0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FH→partner) and Y-score (partner→FH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PMP22 →	-1.142	-0.511	<.001	<.001	3	6
OV	F13A1 →	-1.314	-0.517	<.001	<.001	3	6
OV	CHN1 →	-0.666	-0.350	<.001	.001	3	6
OV	LOXL1 →	-1.384	-0.428	<.001	<.001	3	6
OV	RAB31 →	-1.295	-0.477	<.001	<.001	3	6
COAD	PLK3 →	-0.794	-0.331	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,624 associations by consensus.

FH vs PMP22 — OV

Explore this scatter interactively →