FH

Across TCGA pan-cancer cohorts, FH RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FH’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FH is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

LUAD, THCA, and KIRC are the cancer types where FH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.661	<.001	11	view →
THCA	Male	III,IV	−0.885	<.001	10	view →
KIRC	Male	II,III,IV	−0.816	<.001	9	view →
LIHC	Male	All	+0.672	<.001	9	view →
LUSC	Male	II,III,IV	+0.724	<.001	8	view →
UCEC	All	All	+0.703	<.001	6	view →
BRCA	All	II,III,IV	+0.588	<.001	6	view →
KIRP	All	All	−0.429	.007	2	view →
COAD	Male	All	−0.256	.014	2	view →
BLCA	Female	III,IV	+0.411	.011	1	view →
STAD	All	II,III,IV	+0.258	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FH–LUAD

Open the LUAD breakdown →