FGFRL1

Across TCGA patient cohorts, FGFRL1 mutation is significantly associated with the RNA expression of many other genes, with 999 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGFRL1-associated genes across cancer lineages are OR3A5P, USP12, and SPC24. Each is linked with FGFRL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGFRL1-to-partner and partner-to-FGFRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR3A5P grouped by FGFRL1-low versus FGFRL1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFRL1→partner) and Y-score (partner→FGFRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR3A5P →	+0.065	+4.309	<.001	.007	3	2
UCEC	USP12 →	+0.507	+3.225	.008	.009	3	2
UCEC	SPC24 →	+0.796	+3.807	.003	<.001	3	2
UCEC	TEDC2 →	+0.635	+2.721	.004	.003	3	2
UCEC	STARD4 →	+0.658	+2.700	.007	.006	3	2
UCEC	SCD →	+0.960	+3.191	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 999 associations by consensus.

OR3A5P by FGFRL1 expression — LUSC

Explore this box plot interactively →