FGFR4

Across TCGA cell cohorts, FGFR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,604 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FGFR4-associated GO terms across cancer lineages are Amino acid activation, tRNA aminoacylation, and rRNA modification. Each is linked with FGFR4 in more than 11 cancer types. Because this analysis shows association rather than direction, both FGFR4-to-partner and partner-to-FGFR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amino acid activation grouped by FGFR4-low versus FGFR4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR4→partner) and Y-score (partner→FGFR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Amino acid activation →	+0.080	+1.869	<.001	<.001	3	12
SKIN	tRNA aminoacylation →	+0.080	+1.869	<.001	<.001	3	12
BONE	rRNA modification →	+0.105	+1.708	<.001	.003	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA metabolic process →	+0.056	+1.336	.007	<.001	3	11
SKIN	Negative regulation of purine nucleotide biosynthetic process →	+0.145	+1.544	.002	<.001	3	11
SKIN	Negative regulation of nucleotide biosynthetic process →	+0.145	+1.544	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,604 associations by consensus.

Amino acid activation by FGFR4 expression — SKIN

Explore this box plot interactively →