FGFR3

Across TCGA pan-cancer cohorts, FGFR3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FGFR3 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FGFR3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FGFR3 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, GBM, and LSCC are the cancer types where FGFR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.468	0.922	.007	12	view →
GBM	DFS	Median	All	0.469	0.286	.024	7	view →
LSCC	OS	Tertile	All	1.000	0.876	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FGFR3–HNSC (OS)

Open the HNSC breakdown →