FGFR2

Across TCGA cell cohorts, FGFR2 mutation is significantly associated with the RNA expression of many other genes, with 224 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGFR2-associated genes across cancer lineages are HMHB1, CCR8, and FAM205C. Each is linked with FGFR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGFR2-to-partner and partner-to-FGFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMHB1 grouped by FGFR2-low versus FGFR2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR2→partner) and Y-score (partner→FGFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HMHB1 →	+0.046	+4.437	<.001	.004	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	FAM205C →	+0.070	+4.930	<.001	.008	3	1
BLOOD_Leukemia	GUCA1C →	+0.023	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SERPINB12 →	+0.151	+3.757	.006	.009	3	1
BLOOD_Leukemia	AQP12A →	+0.091	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 224 associations by consensus.

HMHB1 by FGFR2 expression — SKIN

Explore this box plot interactively →