FGFR1OP2

Across TCGA pan-cancer cohorts, FGFR1OP2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FGFR1OP2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where FGFR1OP2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FGFR1OP2 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, PDAC, and COAD are the cancer types where FGFR1OP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGFR1OP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.315	<.001	12	view →
PDAC	All	All	+0.407	<.001	8	view →
COAD	All	II,III,IV	−0.361	<.001	8	view →
LSCC	All	All	+0.084	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FGFR1OP2–CCRCC

Open the CCRCC breakdown →