FGFR1OP2

Across TCGA patient cohorts, FGFR1OP2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGFR1OP2-associated genes across cancer lineages are JNK_pT183_Y185, MSH2, and NDRG1_pT346. Each is linked with FGFR1OP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGFR1OP2-to-partner and partner-to-FGFR1OP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by FGFR1OP2-low versus FGFR1OP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR1OP2→partner) and Y-score (partner→FGFR1OP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.161	-2.321	.028	.034	3	1
UCEC	MSH2 →	-0.209	-3.143	.038	.018	3	1
UCEC	NDRG1_pT346 →	-0.474	-2.999	.027	.035	3	1
UCEC	p62 Lck ligand →	+0.323	+3.179	.023	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.598	+3.189	.021	.010	2	1
UCEC	Caspase-8 →	-0.251	-3.169	.022	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK_pT183_Y185 by FGFR1OP2 expression — UCEC

Explore this box plot interactively →