FGF9

Across TCGA patient cohorts, FGF9 mutation is significantly associated with the RNA expression of many other genes, with 1,048 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF9-associated genes across cancer lineages are LDHA, YTHDF3-AS1, and H3C8. Each is linked with FGF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF9-to-partner and partner-to-FGF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LDHA grouped by FGF9-low versus FGF9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF9→partner) and Y-score (partner→FGF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LDHA →	+0.886	+3.700	<.001	.001	3	2
UCEC	YTHDF3-AS1 →	+0.610	+2.638	.006	.005	3	1
UCEC	H3C8 →	+0.871	+3.593	<.001	.001	3	1
UCEC	RNA5SP411 →	+1.181	+2.393	<.001	.002	3	1
UCEC	RNVU1-28 →	+0.645	+2.050	.001	.007	3	1
SKCM	MAP2K6 →	+0.582	+3.604	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,048 associations by consensus.

LDHA by FGF9 expression — UCEC

Explore this box plot interactively →