FGF9

Across TCGA patient cohorts, FGF9 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF9-associated genes across cancer lineages are STAT3_pY705, ASNS, and EGFR_pY1068. Each is linked with FGF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF9-to-partner and partner-to-FGF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FGF9-low versus FGF9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF9→partner) and Y-score (partner→FGF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.280	-2.321	.034	.035	3	2
UCEC	ASNS →	+0.610	+2.321	<.001	.035	3	2
UCEC	EGFR_pY1068 →	-0.257	-3.000	.041	.036	3	1
UCEC	Notch1 →	+0.230	+3.013	.001	.018	3	1
UCEC	PDCD4 →	-0.620	-2.990	.008	.036	3	1
UCEC	Bak →	+0.298	+3.169	.017	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

STAT3_pY705 by FGF9 expression — UCEC

Explore this box plot interactively →