FGF9

Across TCGA cell cohorts, FGF9 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGF9-associated genes across cancer lineages are HELT, TBC1D21, and PFN3. Each is linked with FGF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF9-to-partner and partner-to-FGF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELT grouped by FGF9-low versus FGF9-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF9→partner) and Y-score (partner→FGF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HELT →	+0.041	+5.321	<.001	.005	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

HELT by FGF9 expression — CNS

Explore this box plot interactively →