FGF8

Across TCGA patient cohorts, FGF8 mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF8-associated genes across cancer lineages are RNU5A-6P, RNU6-1318P, and GTF3AP2. Each is linked with FGF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF8-to-partner and partner-to-FGF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU5A-6P grouped by FGF8-low versus FGF8-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF8→partner) and Y-score (partner→FGF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU5A-6P →	+0.272	+4.653	.001	.007	3	2
UCEC	RNU6-1318P →	+0.481	+3.680	<.001	<.001	3	2
SKCM	GTF3AP2 →	+0.138	+5.037	.003	.009	3	2
SKCM	MIR548AW →	+0.676	+6.624	<.001	.001	3	2
COAD	MIR3667 →	+0.819	+4.899	<.001	<.001	3	2
BLCA	MIR6765 →	+0.307	+5.229	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

RNU5A-6P by FGF8 expression — READ

Explore this box plot interactively →