FGF8

Across TCGA pan-cancer cohorts, FGF8 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FGF8 data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FGF8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGF8 expression acts as an unfavorable survival marker, although some lineages such as STAD and LGG show a favorable association.

ACC, STAD, and SCLC are the cancer types where FGF8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.364	0.767	<.001	112	view →
STAD	OS	Median	II,III,IV	0.758	0.593	<.001	100	view →
SCLC	OS	Tertile	IV	0.137	0.548	.004	54	view →
BRCA	DFS	Quartile	II,III,IV	0.910	0.958	.001	42	view →
LGG	OS	Median	All	0.503	0.382	<.001	40	view →
KIRC	DFS	Tertile	All	0.719	0.837	<.001	40	view →
KICH	DFS	Tertile	II,III,IV	0.043	0.950	<.001	39	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
UVM	DFS	Median	All	0.276	0.599	.015	36	view →
CESC	DFS	Median	All	0.631	0.448	<.001	30	view →
SKCM	OS	Tertile	All	0.250	0.473	<.001	27	view →
KIRP	DFS	Quartile	All	0.403	0.650	<.001	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FGF8–ACC (DFS)

Open the ACC breakdown →