FGF8

Across TCGA patient cohorts, FGF8 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF8-associated genes across cancer lineages are MSH2 and VHL. Each is linked with FGF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF8-to-partner and partner-to-FGF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by FGF8-low versus FGF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF8→partner) and Y-score (partner→FGF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.331	-3.000	.012	.037	1	1
UCEC	VHL →	-1.174	-3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MSH2 by FGF8 expression — UCEC

Explore this box plot interactively →