FGF8

Across TCGA cell cohorts, FGF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,693 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FGF8-associated GO terms across cancer lineages are Regulation of twitch skeletal muscle contraction, Positive regulation of DNA repair, and Subtelomeric heterochromatin formation. Each is linked with FGF8 in more than 7 cancer types. Because this analysis shows association rather than direction, both FGF8-to-partner and partner-to-FGF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of twitch skeletal muscle contraction grouped by FGF8-low versus FGF8-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF8→partner) and Y-score (partner→FGF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of twitch skeletal muscle contraction →	+1.127	+2.692	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of DNA repair →	+0.055	+1.790	<.001	<.001	3	8
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.106	+2.085	<.001	<.001	3	7
LUNG_SCLC	Base-excision repair, gap-filling →	+0.121	+0.643	<.001	<.001	3	7
SOFT_TISSUE	Positive regulation of inflammatory response →	-0.151	-2.909	<.001	<.001	3	7
LARGE_INTESTINE	Regulation of ATPase-coupled calcium transmembrane transporter activity →	-0.164	-0.432	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,693 associations by consensus.

Regulation of twitch skeletal muscle contraction by FGF8 expression — SOFT_TISSUE

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