FGF8

Across TCGA cell cohorts, FGF8 mutation is significantly associated with the mutation status of many other genes, with 834 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGF8-associated genes across cancer lineages are SLC66A1, SPATA7, and LIMA1. Each is linked with FGF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGF8-to-partner and partner-to-FGF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC66A1 grouped by FGF8-low versus FGF8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF8→partner) and Y-score (partner→FGF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC66A1 →	+3.744	+4.044	.003	.003	1	3
LARGE_INTESTINE	SPATA7 →	+5.329	+4.672	<.001	<.001	1	2
LARGE_INTESTINE	LIMA1 →	+3.422	+4.807	<.001	<.001	1	2
LARGE_INTESTINE	ZC3H11A →	+2.744	+4.321	.002	.002	1	2
LARGE_INTESTINE	C5orf22 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	SIM1 →	+2.574	+4.182	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 834 associations by consensus.

SLC66A1 by FGF8 expression — LARGE_INTESTINE

Explore this box plot interactively →