FGF7

Across TCGA patient cohorts, FGF7 mutation is significantly associated with the RNA expression of many other genes, with 3,101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF7-associated genes across cancer lineages are DPH3, SLC4A2, and TRMT61A. Each is linked with FGF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF7-to-partner and partner-to-FGF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPH3 grouped by FGF7-low versus FGF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF7→partner) and Y-score (partner→FGF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DPH3 →	+0.463	+2.847	.001	.001	3	2
UCEC	SLC4A2 →	+0.582	+2.839	.001	.001	3	2
UCEC	TRMT61A →	+0.427	+2.946	.001	<.001	3	2
UCEC	CCNDBP1 →	+0.482	+3.385	.001	.004	3	2
UCEC	UBXN6 →	+0.469	+3.721	<.001	<.001	3	2
UCEC	RGMB →	+0.404	+3.470	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,101 associations by consensus.

DPH3 by FGF7 expression — UCEC

Explore this box plot interactively →