FGF7

Across TCGA pan-cancer cohorts, FGF7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FGF7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FGF7 RNA is repressed in tumor relative to normal tissue. In most cancer types FGF7 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where FGF7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGF7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.637	<.001	12	view →
THCA	Female	II,III,IV	−1.966	<.001	10	view →
KIRP	Female	All	−1.523	<.001	9	view →
UCEC	All	All	−3.694	<.001	8	view →
LUSC	Male	All	−1.620	<.001	8	view →
LUAD	All	III,IV	−0.819	.001	8	view →
BLCA	Male	All	−3.022	<.001	7	view →
HNSC	Male	All	−0.976	.002	7	view →
BRCA	All	III,IV	−1.499	<.001	6	view →
COAD	All	All	−0.745	.001	6	view →
KICH	All	All	+1.368	.002	4	view →
PRAD	All	All	−1.138	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FGF7–KIRC

Open the KIRC breakdown →