FGF7

Across TCGA patient cohorts, FGF7 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF7-associated genes across cancer lineages are C-Raf, Acetyl-a-Tubulin-Lys40, and A-Raf_pS299. Each is linked with FGF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF7-to-partner and partner-to-FGF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FGF7-low versus FGF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF7→partner) and Y-score (partner→FGF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.286	+1.807	<.001	.027	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.652	+3.000	.039	.036	3	1
UCEC	A-Raf_pS299 →	-0.117	-2.459	.017	.019	3	1
UCEC	FoxM1 →	+0.349	+2.321	.001	.006	3	1
UCEC	JNK2 →	+0.242	+2.196	.003	.032	3	1
UCEC	Ku80 →	+0.303	+1.820	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

C-Raf by FGF7 expression — UCEC

Explore this box plot interactively →