FGF6

Across TCGA patient cohorts, FGF6 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF6-associated genes across cancer lineages are Rab25, Annexin-1, and Cyclin-B1. Each is linked with FGF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF6-to-partner and partner-to-FGF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by FGF6-low versus FGF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF6→partner) and Y-score (partner→FGF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.370	-3.459	.005	.005	3	2
UCEC	Annexin-1 →	+0.629	+2.415	.002	.003	3	2
UCEC	Cyclin-B1 →	+0.752	+3.459	<.001	.005	3	2
SKCM	SF2 →	-0.299	-3.000	<.001	.036	3	2
UCEC	14-3-3_beta →	-0.124	-2.432	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.256	-3.169	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Rab25 by FGF6 expression — UCEC

Explore this box plot interactively →