FGF6

Across TCGA pan-cancer cohorts, FGF6 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated FGF6 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher FGF6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FGF6 expression acts as an unfavorable survival marker, although some lineages such as UCS and SARC show a favorable association.

MESO, UCS, and ACC are the cancer types where FGF6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	IV	0.056	0.640	<.001	90	view →
UCS	DFS	Median	II,III,IV	0.535	0.153	.005	38	view →
ACC	OS	Tertile	All	0.191	0.728	.001	36	view →
THCA	OS	Tertile	IV	0.095	0.966	<.001	30	view →
THYM	DFS	Tertile	III,IV	0.208	0.813	.003	27	view →
SARC	DFS	Tertile	All	0.495	0.294	.011	26	view →
BRCA	OS	Tertile	III,IV	0.163	0.563	.015	24	view →
DLBC	OS	Tertile	III,IV	0.172	1.000	.014	18	view →
LUAD	OS	Tertile	III,IV	0.230	0.676	.001	18	view →
KIRC	DFS	Tertile	IV	0.222	0.516	.018	18	view →
ESCA	OS	Quartile	II,III,IV	0.532	0.724	.031	10	view →
COAD	DFS	Tertile	IV	0.035	0.501	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

FGF6–MESO (OS)

Open the MESO breakdown →