FGF6

Across TCGA cell cohorts, FGF6 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGF6-associated genes across cancer lineages are ACER1, OR1C1, and SPACA1. Each is linked with FGF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF6-to-partner and partner-to-FGF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by FGF6-low versus FGF6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF6→partner) and Y-score (partner→FGF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.105	+3.823	<.001	.006	3	1
LARGE_INTESTINE	OR1C1 →	+0.076	+3.684	<.001	.006	3	1
STOMACH	SPACA1 →	+0.023	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ACER1 by FGF6 expression — LARGE_INTESTINE

Explore this box plot interactively →