FGF5

Across TCGA cell cohorts, FGF5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FGF5-associated genes across cancer lineages are PAX4, CHRNB3, and FUT5. Each is linked with FGF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF5-to-partner and partner-to-FGF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX4 grouped by FGF5-low versus FGF5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF5→partner) and Y-score (partner→FGF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PAX4 →	+0.017	+4.467	.005	.004	3	1
SKIN	CHRNB3 →	+0.011	+4.467	<.001	.004	3	1
LARGE_INTESTINE	FUT5 →	+0.020	+4.242	.002	.001	3	1
LARGE_INTESTINE	CACNG3 →	+0.004	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PAX4 by FGF5 expression — SKIN

Explore this box plot interactively →