FGF5

Across TCGA pan-cancer cohorts, FGF5 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of FGF5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FGF5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FGF5 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

HNSC, BRCA, and KIRP are the cancer types where FGF5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGF5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.145	<.001	10	view →
BRCA	All	All	+0.160	<.001	8	view →
KIRP	All	All	−0.318	.005	7	view →
LUSC	All	All	+0.360	<.001	4	view →
LUAD	Male	All	+0.186	.004	4	view →
KICH	Female	All	−0.225	.003	2	view →
LIHC	All	II,III,IV	+0.005	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

FGF5–HNSC

Open the HNSC breakdown →